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The Lancet's Editorial

Specifically, phentermine: Activates norepinephrine and dopamine release to decrease hunger and food intake Increases resting metabolism to burn more calories Elevates body temperature, facilitating fat burning Intensifies fat breakdown in adipose tissue Improves glucose tolerance and lowers insulin levels This powerful neurological impact reduces appetite, limits calorie intake, and optimizes fat burning

Gut 58 , 4148 (2009)