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Consumption is also not recommended for people who must perform activities requiring sustained attention where drowsiness could pose a safety problem

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Onceweekly IcoSema versus onceweekly semaglutide in adults with type 2 diabetes: the COMBINE 2 randomised clinical trial published online 17/01/2025 Ildiko Lingvay, Malik Benamar, Liming Chen, Ariel Fu, Esteban Jdar, Tomoyuki Nishida, JeanPierre Riveline, Daisuke Yabe, Thomas Zueger, Rosngela Ra For many people living with type 2 diabetes, the progressive nature of the disease means that insulin therapy often becomes necessary once non-insulin glucose-lowering therapies can no longer maintain acceptable glycaemic control

The reason this matters: lyophilized peptide is a fragile, porous structure