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While classical gene mutations are region-limited, epimutations often occur early in cancer development and have a genome-wide impact, boosting on the one hand the expression of cell survival genes or proto-oncogenes and deactivating on the other hand tumor suppressor genes (TSGs), DNA repair mechanisms as well as cell division brakes, thus leading to carcinogenesis (Karius et al., 2012

These models can be used to explore the pathogenesis of ALD at different stages or different degrees of severity, and provide research tools for discovering new drug targets with potential for the treatment of ALD

J Neurochem 37:16181621 Willett W, Rockstrm J, Loken J et al (2019) Food in the anthropocene: the EAT-Lancet Commission on healthy diets from sustainable food systems

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