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reports personal fees from Allena, Oxthera, Sanofi, Fresenius Medical Care, Alnylam Pharmaceuticals, Advicenne, Medice and Zai, and grant support from Alnylam and Dicerna Pharmaceuticals

Main exclusion criteria included BMI 20 kg/m, type 1 diabetes mellitus, type 2 diabetes mellitus, previous treatment with insulin or with oral hypoglycemic or insulin-sensitizing agents, history of malignancy, and hypopituitarism

There are cases where topical delivery makes sense GHK-Cu copper peptide is one example where topical application has reasonable evidence for collagen stimulation at the skin surface

Melsmon has the advantage of less pain during injection because it has a pH close to neutral and contains benzyl alcohol as a pain-relieving component