Janet Travell, a physician who did extensive research on trigger points, found that histological changes such as myogelosis (abnormal hardening), hypoxia (lack of oxygen) and build up of metabolic wastes can occur in trigger points, especially if left untreated (1)
related full-length recombinant thymosin beta-4 (a different formulation than the marketed TB-500 fragment) has also been examined in small human studies for cardiac and dermatologic indications Examined in preclinical models, including diabetic rat Achilles tendon and rat ligament-injury studies, for actin-binding, cell-migration, and angiogenic activity that researchers have proposed as a mechanism for tendon and ligament repair, though this literature remains comparatively sparse for musculoskeletal applications specifically Known risks and side effects: Because TB-500 is manufactured and sold without FDA oversight as a "research chemical," independent testing and industry reporting describe wide variability in purity (with some products measured well below labeled potency) and contamination with heavy metals or bacterial byproducts, unlike pharmaceutical-grade recombinant thymosin beta-4 used in registered clinical trials Thymosin beta-4's core mechanisms, angiogenesis and cell migration, are also pathways exploited by tumors
High-dose niacin therapy is normally contraindicated in individuals with active peptic ulcer disease or active liver disease
Bacteriostatic Water: This is sterile water containing 0.9% benzyl alcohol, which acts as a preservative to prevent the growth of bacteria
