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Inflammation and gut microbiota play crucial roles in both psychological distress and liver disease initiation and progression, while the sickness behavior theory explains that peripheral inflammation can lead to behaviors like fatigue, lethargy, impaired concentration, and social withdrawal

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Studies indicate that basal and glucose or meal-stimulated levels of amylin are elevated in individuals with obesity ( Calcitonin Calcitonin is a 32-amino acid peptide hormone ( Table 1 ) derived from the 116-amino acid precursor pro-calcitonin and secreted from the C cells of the thyroid gland