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Vitamin B12 shots are often prescribed for people with: Pernicious anemia (autoimmune destruction of intrinsic factor needed for B12 absorption) Gastrointestinal surgeries (e.g., gastric bypass, ileal resection) Crohns disease or celiac disease Chronic alcoholism Long-term use of acid-reducing medications Vegan diets without supplementation Infants or children with congenital absorption disorders (i.e., vitamin B12 for kids in clinical care) Injections ensure direct delivery into the bloodstream, bypassing the digestive system entirely

Since the NP is a confined, avascular space, the injected factor may be retained for long time

Cross-reactivity in drug hypersensitivity reactions to sulfasalazine and sulfamethoxazole