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PERK activity has also been utilized by cancer cells to adjust the proliferation-related rate of protein synthesis to modulate growth rates (Atkins et al

These authors concluded that the proportion of LBM relative to total body mass increased with semaglutide. Similarly, in the SURMOUNT-1 trial which studied tirzepatide, researchers found that participants treated with tirzepatide had a percent reduction in fat mass approximately 3 times greater than the reduction in lean mass, resulting in an overall improvement in body composition. More recently, a viewpoint in JAMA re-grounded the conversation: weight loss in persons with obesity primarily reduces body fat, but also decreases fat free mass (FFM)

Seri K, Sanai K, Matsuo N, Kawakubo K, Xue C, Inoue S

In many patients, excess weight is part of a larger cardiometabolic disease process