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For othersespecially those with higher demands, specific medications, metabolic issues, or aggressive weight-management planssupplementing into a higher, therapeutic range can make sense

Other metaplastic changes have also been described in the human gallbladder, including goblet cells, paneth cells, and/or enterochromaffin cells in the mucosa (Hruban, Argani, and Ali 2006)

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Despite the adverse effects described, the KD usually does not have long-term tolerability, which not just introduces barriers to compliance by caregivers and patients but also compromises the clinical efficacy of the therapy