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It binds GHS-R1a with high affinity but shows minimal activity at other receptor systems, including those mediating cortisol release (CRH/ACTH axis), prolactin release, or appetite stimulation pathways independent of GH signaling

Kirke PN, Mills JL, Molloy AM, Brody LC, OLeary VB, Daly L, et al

While these findings come from animal and cell culture models rather than human clinical trials, the consistency of the respiratory protection data across multiple study designs and injury types is compelling