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Author Contributions Study concept and design: Kumar, Pagali, Singh

Overdosing drives side effects that reduce adherence and adherence, not peak dose, is the variable most predictive of long-term metabolic outcomes

Results and discussion Ice nucleation activity of RuBisCO compared with other abundant biomolecules Ice nucleation measurements were conducted in immersion mode using our custom-built ice microscope apparatus using a droplet volume of 2 L with a minimum of 5 independent replicates and up to 25 freeze-thaw cycles for each replicate 10,51