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A single missed dose has minimal impact on overall results

of VA Medical Center, Memphis, University of Tennessee, for his intellectual insights, help in figure drawing, and reading the manuscript

Studies examining safety and tolerability in rodents have generally not reported concerning toxicity signals at doses producing metabolic benefits, though comprehensive toxicology studies and long-term safety data are limited

For example, sugar alcohols like sorbitol or mannitol (used in some chewable or effervescent preparations) can have osmotic effects, drawing water into the intestinal lumen and potentially leading to loose stools in sensitive individuals