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Mitochondrial bioenergetic deficit precedes Alzheimers pathology in female mouse model of Alzheimers disease

Milk thistle may also interact with the following medications, though the interactions are less concerning and only require monitoring after ingestion:2 Fosphenytoin-phenytoin Indinavir Losartan Metronidazole Sirolimus Tolbutamide Vitamin K antagonists On the brighter side, most adverse reactions to milk thistle are minor and brief

Signal Transduction and Targeted Therapy, 8 , 345

Clinicians typically start patients at the middle ODT dose (5 mg) when switching from low-dose injectables (0.25 to 0.5 mg weekly) and titrate based on response