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Metabolism 42 , 14431447 (1993)

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Pigmentation without appetite suppression suggests the compound is binding MC1R (melanocytes) but not effectively crossing the blood-brain barrier to reach MC4R (hypothalamus)

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That difference comes down to one thing: solubility

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The debilitating fatigue which seems to be the most common symtpom of B12 deficiency may be due to a combination of neurological factors, anaemia, and the role of B12 in the mitochondria

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