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A patient on semaglutide who transitioned to a ketogenic diet reported initial gastrointestinal discomfort and difficulty adhering to the diets strict carbohydrate restrictions

Variation in the plasma membrane monoamine transporter (PMAT) (encoded by SLC29A4) and organic cation transporter 1 (OCT1) (encoded by SLC22A1) and gastrointestinal intolerance to metformin in type 2 diabetes: an IMI DIRECT study

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The tesofensine article covers a compound that approaches weight loss through neurotransmitter modulation, providing appetite suppression through a completely different mechanism than GLP-1 agonists