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Once activated, AMPK first directly affects the activity of key enzymes of glucose metabolism and fatty acids, and second, proceeds to the long-term regulation of the transcriptional control of the main elements involved in these metabolic pathways

in non-critical cases, 100180 mg/dL (5.610.0 mmol/L) is acceptable if achievable without hypoglycaemia

Human neuroimaging studies mirror this: fitter older adults tend to have larger hippocampal and prefrontal volumes and better cognitive test scores ( 3.5 Challenges: blunted adaptations and frailty Despite these benefits, older adults face some limitations

10.1186/s12967-017-1175-y J Transl Med