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The constipation rate in particular (24.2%) is something to be aware of if you have IBS-C

[130][131][132][133][134][135] Liraglutide has been also been reported to improve -cell function as measured by HOMA-B analysis and proinsulin/insulin ratio.87,88 In a 12-week comparison study, comparing liraglutide (doses ranging from 0.045 mg/day to 0.75 mg/day) to metformin (1000 mg bid), it was reported that liraglutide at doses 0.45 mg/day achieved a similar level of glycemic control to metformin, measured by A1C and fasting plasma glucose

Orforglipron also reportedly has a simpler production process than injected GLP-1 drugs such as Ozempic and tirzepatide (sold as Mounjaro) and does not require cold storage factors that could help improve access to the drug if it is approved for use

However, these effects were mild