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Naltrexone (TRMP3 variant): A 2019 cell study using CFS/ME cells from 8 different patients showed that Naltrexone restored TRPM3 function.[ref] Keep in mind that this is just a cell study (not a randomized, double-blind, placebo-controlled trial), but it may be worth talking with your doctor about this study, especially if you carry a TRPM3 variant linked to CFS

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice