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Cell Death Dis 11(5):359

NAD + is also a precursor to cyclic ADP-ribose (cADPR), a secondary signaling molecule generated by enzymes such as cluster of differentiation 38 (CD38) 7 , and it can be hydrolyzed by sirtuins, which deacetylate histones and regulate gene expression 7

Autocrine GH enhances cell viability, clonogenic survival, and DNA repair in breast and endometrial cancers after ionizing radiation (Wu et al., 2014), whereas the over-expression of GHR in rectal cancer is predictive factor for tumor response to preoperative radiotherapy (Wu et al., 2006)

[DOI] [PubMed] [Google Scholar] 268.Xiao J.B., Hgger P