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In general, the diagnosis is clinical and no laboratory tests or biopsies are required

Experimental studies in rat models have shown that the activity of the 20S proteasome decreases with age, which is accompanied not only by a reduction in its quantity but also by changes in the composition and structure of its subunits

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The goal of PN clinical treatment is to relieve metabolic problems, repair nerves, reduce oxidative stress, and improve microcirculation and other clinical symptoms