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However, prolonged therapy may modestly reduce B12 absorption, making supplementation prudentespecially for patients over 50 or with a history of deficiency

Key Highlights: Primary Endpoint Met: Orforglipron achieved superior A1C reduction vs placebo at 40 weeks: A1C reduction: 1.3% to 1.6% vs 0.1% for placebo Over 65% of patients on highest dose reached A1C 6.5% Promising Weight Loss: Patients on the highest dose experienced an average weight loss of 7.9%, with Lilly noting the effect hadnt yet plateaued

Rare side effects include pancreatitis and thyroid concerns in predisposed individuals

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