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FDA's concerns with unapproved GLP-1 drugs used for weight loss

Recently, two mechanisms involved in the gut-brain axis have attracted increasing attention due to their role in the pathogenesis and progression of PD, namely, disruption of the composition of microorganisms living in the intestine (intestinal microbiome) and dysfunction of enteroendocrine cells, accompanied by impaired signaling through the GLP-1R [60]

People on the highest dose of orforglipron lost on average around 10% of their baseline body weight, for instance, compared to the 2.5% average weight loss seen in those taking a placebo