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Methods Animal model and treatment All experimental mice used in this study were male, C57BL/6J background

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Interestingly, the accumulation of native amylin aggregates in the pancreas may itself contribute to beta-cell death in T2D, making amyloidogenicity both a formulation problem and a potential disease mechanism

[PMID: 24283226 DOI: 10.1056/NEJMra1208707] [DOI] [PubMed] [Google Scholar] 44.Griffiths MJD, Evans TW