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Notably, the drug leakage and release kinetics of MNMs during delivery are critically governed by their drug-loading configurations and post-targeting behavior within the lesion microenvironment, which collectively modulate their therapeutic efficacy and biosafety profiles

Artery-derived VEGF-C promotes artery development In the adult intestine, the VEGFR3 ligand VEGF-C is expressed by vascular and intestinal smooth muscle cells (SMCs), macrophages, and a subset of villus fibroblasts 56,57,58

doi:10.1056/NEJMcp1113996 2Socha DS, DeSouza SI, Flagg A, Sekeres M, Rogers HJ

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