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Time-lapse light microscopy observation of wound closure revealed that A375 cells treated with HC exhibited a reduced migration rate compared to both untreated (DMEM) and DMSO-treated cells

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Since HCV isolates apart from JFH1 require massive adaptation to allow infectious particle production 22 , including the GLT1 isolate 21 , we employed chimeric genomes encoding the JFH1 replicase fused to the pre- and post-transplant structural proteins to assess changes in infectious particle production 23 (Fig