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To identify new regulators of GSC proliferation, we used ethyl methane sulphonate (EMS) to randomly mutagenize a mutant strain carrying a conditional glp-1 gain-of-function ( gf ) allele, which causes the formation of proximal undifferentiated benign germline tumours under restrictive conditions 19,20,21

Large registry-based studies found no increased risk for ileus, intestinal obstruction, pancreatitis, gallbladder disease, or other serious adverse events among patients with IBD receiving GLP-1 RAs

This may be because their body is producing less or not responding to normal levels