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Titration Design In the Phase 2 trial published in The New England Journal of Medicine , participants started on a low introductory dose (as little as 24 mg weekly) and were titrated upward over the course of several weeks before reaching target doses of 812 mg

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The acquisition parameters were as follows: echo time (TE) of 3.4 ms, repetition time (TR) of 7.4 ms, flip angle of 8, field of view (FOV) of 220 220 mm, slice thickness of 1 mm, and 180 contiguous sagittal slices