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First, start berberine at a low dose (typically 500 mg once or twice daily) and titrate slowly over 2-3 weeks while monitoring blood sugar, energy levels, and gastrointestinal symptoms

Most people use over-the-counter pain medication like Tylenol for recovery if needed

Long-term diabetes can lead to an increase in myocardial collagen fibers and the degree of collagen cross-linking, which will aggravate myocardial fibrosis, make the myocardium stiffer, and raise the likelihood of heart conditions like heart attack and high blood pressure (Flier et al., 1988)

Austin, TX: Texas State Legislature