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STEER was a retrospective, observational real-world study, evaluating the efficacy of semaglutide 2.4 mg versus tirzepatide for the prevention of MACE in US adults with overweight or obesity and established CVD with no prior history of diabetes, with a primary outcome measure of revised 5-point MACE (heart attack, stroke, hospitalisation for heart failure, coronary revascularisation, and death from any cause) and revised 3-point MACE (heart attack, stroke and death from any cause)

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Kushner, lead author of the study and an obesity researcher at Northwestern University Feinberg School of Medicine who works with Novo Nordisk, called the drug a "game-changer" in an interview with The New York Times