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And dulaglutide increased the expression of proteins associated with lipolysis and fatty acid oxidation, as well as family with sequence similarity 3 member A (FAM3A) [56]
Given the relatively smaller reduction in body weight (9.4%) in the SELECT trial compared to previous RCTs: 14.9% in STEP1 (BMI 37.86.7 kg/m 2 ) [16] and 13.2% STEP6 (BMI 31.9 kg/m 2 ) [49], pleiotropic effects of semaglutide may contribute to the overall CV risk reduction [25,37]
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Some areas the scientists focused on included animal studies on Alzheimers and Parkinsons diseases, dementia risk in people with a background of obesity or type 2 diabetes, and cognitive functioning tests in people with obesity or diabetes
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