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In this context, elegant studies published by Ira Tabass group have contributed to the understanding of cellular metabolism by demonstrating that macrophages use amino acids, such as arginine and ornithine, derived from the degradation of ACs to synthesize putrescine that activates Rac1, which stabilizes the machinery required for actin remodeling and plasma membrane projection, supporting continuous efferocytosis

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Although contribution of the adaptive immunity in F11r(+/+)Rag1(/) mice was observed at negligible levels, F11r(/)Rag1(/) mice exhibited increased microbiota-dependent colitis

doi: 10.1155/2009/132041