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Both medications can: Help improve blood sugar control and lower A1c levels, a key marker of blood sugar control Aid in weight loss, although Ozempic may be more effective for this benefit Reduce the risk of cardiovascular events, such as heart attacks and strokes, in people with type 2 diabetes Common side effects The common side effects of Rybelsus and Ozempic include: Nausea Vomiting Diarrhea Constipation Abdominal pain Decreased appetite These side effects are generally mild and tend to lessen over time as your body adjusts to the medication