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In one meta-analysis of RCTs, metformin worked about three times as well when starting a new antipsychotic in first-episode psychosis (about a 13-pound difference from placebo) compared with its use after chronic antipsychotic treatment (about a 4-pound difference from placebo) (De Silva VA et al, BMC Psychiatry 2016;16(1):341)

Bleyer A, OLeary M, Barr R, et al., eds.: Cancer Epidemiology in Older Adolescents and Young Adults 15 to 29 Years of Age, Including SEER Incidence and Survival: 1975-2000

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