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The fact is, our biology is programmed for a very different environment than our current surroundings

This work defines a carnitine-facilitated route to produce nuclear-cytosolic acetyl-CoA, shedding light on the intricate regulation and compartmentalization of acetyl-CoA metabolism INTRODUCTION Acetyl-CoA is a central metabolic intermediate that is generated during nutrient catabolism, used as a building block for lipid synthesis, and serves as the substrate for protein and metabolite acetylation

Cold Spring Harbor symposia on Quantitative Biology (Cold Spring Harbor Laboratory Press, 2007)

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