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The bottom line GLP-1 drugs cause muscle loss, but not uniquely the ratio is similar to dieting or surgery

Most importantly, these results indicate that ghrelin has the potential to amplify dopamine signaling selectively in neurons that coexpress D1R and GHS-R

GLP-1s are also not appropriate for : Individuals who are underweight or undernourished Those at risk for sarcopenia (muscle loss) People with low muscle mass or nutritional deficiencies Adults over 65 with osteopenia, osteoporosis, or a recent history of fractures In these cases, reduced appetite and unintended weight loss can accelerate muscle and bone loss, making close medical supervision essential

The effectiveness of MIC B12 injections can vary among individuals