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There are currently five medications on the FDA-approved list for long-term use for weight loss: Wegovy (semaglutide) Saxenda (liraglutide) Xenical and Alli (orlistat) Qsymia (phentermine-topiramate) Contrave (bupropion/naltrexone) The above list does not include medications indicated for short-term use such as phentermine or medications prescribed off-label like Ozempic or Mounjaro

A UK news investigation in early 2026 found that people with a healthy BMI could easily obtain prescription-only injections from online pharmacies by submitting AI- or photo-edited images that made them look larger