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We hypothesized that the observed lower GSH:GSSG ratio in asthmatic lung fluids and cells is at least partially driven by high oxidation of GSH and its export in response to greater intracellular 15LO1/PEBP1 pathway activity

But other researchers have found Nox4 is considered to be the main active subtype of chondrocytes in OA cartilage, in which the activation of Nox4 by proinflammatory cytokines increases the production of O 2 and H 2 O 2 (Morel et al., 2015)

For ease of comparison and calculation, the term pKb is used to represent the strength of a base and is defined as: pKb = -log(Kb)