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After infectious or sterile stimuli, SLC15A4 in DCs is recruited to phagosomes, SLC15A4deficient DCs infected with Salmonella typhimurium show reduced caspase-1 cleavage and IL-1 production, this correlates with peripheral NLRC4 inflammasome assembly and increased autophagy

In an in vitro model of diabetes retinopathy, AC, reduced retinal pigment epithelial cell damage through inhibiting Keap1 expression, endorsing nuclear translocation of Nrf2, elevating NQO1 and HO-1 expression, reducing ROS, and increasing superoxide dismutase (SOD), total antioxidant capacity (T-AOC), and glutathione peroxidase (GSH-Px) (Yang et al