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B12 : 1

Typically, before a drug can be marketed, it must pass through a series of clinical trials, in order to identify safe dosages and to determine that any positive outcomes are due to the substance itself, and not to bias in the study design

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As examples, some of these predictions are stated here: Under conditions of B12 insufficiency, excess folic acid intake will cause the following: Diversion of holoTC from serum to hemopoietic cells to support reticulocyte proliferation Loss of holoTC in urine due to interference of its reuptake by the megalin-receptor complex in the renal tubules Reduced availability of holoTC to the liver, brain, and other tissues due to its diversion to the hemopoietic system and loss in the urine