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More recently, a randomized placebo-controlled trial on NS workers assessed melatonin supplementation before day sleep for four weeks, showing a significant increase in urinary 8-OHdG, biomarker of oxidative DNA damage repair, during day sleep 30

Definition Box Signal Peptide: A short peptide sequence that triggers downstream cellular responses (gene expression, enzyme activation, cytokine release) by interacting with receptors or transport proteins rather than by being incorporated into larger structures

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