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(2021) synthesized a dual-targeting phosphatidylinositol-3-kinase and histone deacetylase inhibitor BEBT-908 that robustly reduces tumor cell proliferation and enhances the efficacy in antiprogrammed cell death protein 1 immunotherapy in mice by triggering immunogenic ferroptosis, demonstrating BEBT-908 would be a potential targeted therapeutic medicine against various cancer types (Fan et al., 2021)

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