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4.1
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Th1 chemokine interferon inducible protein 10 (IP-10) levels have been shown to be elevated in BAF of asthmatic children, and apigenin also reduced its production by monocytes, coinciding with inhibited phosphorylation of JNK and MAPK pathways [140]

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Therefore, ferroptosis enhances M1-type macrophage polarization, worsens peripheral inflammation, and accelerates AS progression (Ma et al., 2022)

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Cell Metab 2018;27:74056.ArticlePubMed 33

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