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The most substantial weight reduction in the phase 2 trial was observed from weeks 12 onwards , during which participants were approaching or at their target dose

In the SURMOUNT clinical trial series, participants maintained weight loss for up to 2 years when continuing the medication, losing an average of 2022% of body weight at higher doses

Buyer Takeaway: The 2026 approval of oral GLP-1 pharmaceutical options means the "needle-free" positioning that defines this supplement category now has pharmaceutical competition it didn't have 18 months ago

But dropping your working weights signals to your body that you no longer need the muscle you built