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The first direct empirical evidence for this principle emerged nearly three centuries later from the work of German pharmacologist Hugo Schulz

Fasting or fasting-mimicking diet In addition to CR, alternative approaches such as intermittent fasting (IF), including short-term fasting (STF), intake of an FMD, and time-restricted feeding (TRF), which limits food consumption to a specific time window each day, are being condisered

Cui, W., Guo, M., Liu, D., Xiao, P., Yang, C., Huang, H., Liang, C., Yang, Y., Fu, X., Zhang, Y., Liu, J., Shi, S., Cong, J., Han, Z., Xu, Y., Du, L., Yin, C., Zhang, Y., Sun, J., & Chu, B

The Gut Microbiome and the Brain