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To counteract this and make the drug effective for a longer time, inhibitor molecules like that in PDB entry 3gss can be administered along with the drug to inhibit the action of the enzymes

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W., James, L., Hahn, P

Because there were potential reproductive abnormalities observed in preclinical toxicity studies in Sprague Dawley rats and cynomolgus monkeys (see Supplementary Results for complete details of these preclinical studies), out of an abundance of caution, we restricted female subjects to postmenopausal women of nonchildbearing potential