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Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation

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Regeneration of Other Antioxidants Glutathione directly recycles and regenerates other antioxidants that have been oxidized and inactivated: Vitamin C (ascorbate): GSH reduces dehydroascorbate back to ascorbate Vitamin E (alpha-tocopherol): GSH supports regeneration of oxidized tocopheryl radical Alpha lipoic acid (ALA): GSH participates in maintaining ALA in its reduced form This regenerative cascade is what distinguishes glutathione from most other antioxidants