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Reportedly, lactate in the TME induces H3K18la modification, which regulates immune cell functions by enhancing the transcriptional activity of CD39, CD73, and CCR8 gene promoters

Moreover, in B cells, glutamine deprivation-induced inhibition of mTOR activation can promote GSK3 inhibition and suppress IL-10 secretion [161]

Statistical Analysis All data from the current study are shown as means standard deviation (SD), except for behavioral tests, which are presented as means standard error of the mean (SEM)

In addition, multiple transcription factors, such as ATF3, ATF4, P53, Nrf2, and c-Myc, have been identified as the regulators of SLC7A11 and SLC3A2 transcription [11, 27,28,29,30]