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Louis Aronne is a paid consultant and advisory board member for Eli Lilly and Company, the study sponsor and the manufacturer of orforglipron and tirzepatide.

Its involvement at the intersection of metabolic regulation, stress responsiveness, and reproductive endocrinology positions it as a candidate for conditions in which these domains converge, such as menopause-associated metabolic dysfunction or stress-related eating disorders

The before-and-after tirzepatide outcomes in this BMI category are among the most dramatic documented in clinical practice

a gradual dose-escalation schedule is used in trials to minimise discomfort