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We further determined that the underlying mechanisms of the protective effects by TB001 involve enhancing lipid metabolism related pathways and inhibiting key pro-fibrotic pathways, such as TGF-1/Smad2/3/Twist and PKC signaling

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Studies that used 1 mg/day in oral and intravenous trials did not show meaningfully better outcomes than lower doses, and higher doses were associated with more reports of headache, diarrhea, and gastrointestinal effects

Our topical protocols use concentrations validated in clinical studies, applied alongside complementary ingredients that enhance penetration and efficacy