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demonstrated that administration of 0.001 mg/kg body weight THC resulted in a sustained impairment of cognitive performance in mice, as evaluated using the Morris Water Maze, with effects persisting for at least 3 weeks (Tselnicker et al., 2007)

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This elevation in NAD+ levels activates critical metabolic pathways including SIRT1 (sirtuin 1), a longevity-associated protein that regulates insulin sensitivity, mitochondrial function, and cellular stress resistance